Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
ABSTRACT Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, Treatments - Cold thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.Importantly, although ADEP-activated ClpP is assumed to target multiple polypeptide and prot